tag:blogger.com,1999:blog-4073397588746430486.post3698327455685828160..comments2023-10-30T22:11:21.083-10:00Comments on Lyme Disease, Science, And Society: Camp Other: Commentary: Finding the right treatment that worksCamp Otherhttp://www.blogger.com/profile/10224408965529778101noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-4073397588746430486.post-44299249334564377692013-11-04T22:40:46.870-10:002013-11-04T22:40:46.870-10:00(My above comment was longer, but the software did...(My above comment was longer, but the software did not permit more than ca. 4000 ?keystrokes - such limitations should be indicated in advance... -- Here is the rest of my text:)<br /><br />I have been advocating this approach for 10 or more years (to be considered also in MS, which most probably is a severe - demyelinating - form of NB), mostly in German. I remember only one MS victim to report a similar scheme with 3 week intervals - which had kept ?him (or her) free of bouts / in remission.<br /><br />Such a scheme could be "generalized" for millions: in this case the remarkably low dose (i.e. per year) is a big advantage, because much of the doxy - as is the case with many other antimicrobials - is excreted and reaches the sewage treatment ?plants. High concentrations of antimicrobials might interfere with the microbiology there...<br />(Doxy is a standard drug in acne, at 50 or 100 mg/d = ca. 182 or even 365 x 100 mg per year, that is more than I need and much more than a lighter person with ca. 12 x 500 mg = ca. 60 x 100 mg per year needs on my scheme.)<br /><br />I should mention that in parallel with the start of my AB "experimentation" I got rid of some 2,5 - 3 g of stored iron (serum ferritin ca. 300 ng/ml) by a series of phlebotomies (analogous to blood donations), and have kept my ferritin at <25 ng/ml thereafter.<br /><br />B.b is said to need NO iron for multiplication, but that can be / almost certainly is different for various co-infections. <br />Iron in the CNS most probably is a central cause for neurodegeneration: I am very confident that I will not be demented as long as I shall live (and I am quite confident to not get lots of other diseases of older age - but that's another "story"; Randall B. Lauffer 1991-93 wrote 3 books on that matter, or do some searching for Jerome L. Sullivan, Jukka T. Salonen / ... Tuomainen, Eugene Weinberg, Francsco S. Facchini, Leo R. Zacharski, S.V. Shah...).<br />chen-men <br /><br />(The writing-images which must be copied at the end of commenting are almost undecipherable! It's really no "fun" to comment on this blog.! It's al little sadistic, isn't it?)Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-4073397588746430486.post-73077936400741360722013-11-04T13:49:44.922-10:002013-11-04T13:49:44.922-10:00Hello,
I'm German, so excuse poor English. I a...Hello,<br />I'm German, so excuse poor English. I am "camp other" too, as a (medical) scientist over more than 2 decades have worked out my own view of LB and NB (neuroborreliosis).<br /><br />I think that LB outside of the CNS can be cured by doxycycline. Doxy is well tolerated (not for children!), so it can be taken repeatedly.<br /><br />Once B.b(urgdorferi) reaches the CNS it's a completely different problem. It's known that B.b can form "spores" (cysts...) which are insensitive to common antimicrobials, e.g. doxy. I'm not aware that anyone has a "sure fire" therapy to CURE chronic NB.<br /><br />So to me it's logical to fight back those B.b that can be reached, and after a while (pause, interval) hit those that have reverted to the spirochete from the "spore" form.<br /><br />Prof. Vera Preac-Mursic in the ?early 90s proposed a pulse protocol: With a pulse of an effective AB you kill a lot (most) of the normal B.b. The remains have to be cleared up by the immune defence (possibly the AB and that defence unite in killing B.b?), which will sort of "train" the immune defence.<br />That pulse treatment was demonstrated with cefotaxim once per week in collaboration with Dr. Dieter Hassler, a "Lyme specialist" in Germany, in a LANCET letter.<br /><br />Because the i.v. ABs are (at least were) extremely expensive, have risks and need someone to do the i.v. application I decided to try a pulse protocol with doxy.<br />After a few ?years (LONG ago) I came up with this scheme (for a person of maybe 80...90 kg): 300-100-100-100-100-100 mg at an interval of ca. 8h (= 800 mg / 2 days). 300 is the "loading dose", the rest will keep the doxy level relatively high to get the lipophilic substance into the CNS, which obviously will take some time. (The initial 300 mg may cause some stomach irritation, so the 3 x 100mg could be spread over several hours, i.e. first 100 (or 200) mg with supper, the other before going to sleep.)<br />A lighter person might use 200-100-100-100 mg with an interval of ca. 12 h (= 500 mg / 2 days).<br />These "pulses" of 2 days dosing (and probably a somewhat longer antimicrobial effect because of a half life of elimination of almost a day) I repeat once per months. (Earlier the pauses were shorter, but my experience is that a month is ok with me - much longer than the week ?suggested by Hassler and Preac-Mursic.)<br /><br />I have been doing this for more than 10 years by now - and finally have the impression that I got rid of all variable symptoms (there are a few that seem to be permanent, like numbness in both feet). I wonder if there are practically no "spores" left by now. But for the time being I do not dare to stop this scheme.<br /><br />I need ca. 100 x 100 mg per year, which I have managed to obtain from a number of different doctors over all the years.. (Cost is "ridiculously" low, compared to the i.v. "third generation" cephalosporines; ceftriaxone and cefotaxime.) <br /><br />I doubt that B.b can develop resistance to doxy (at least with this pulse - interval scheme). Detailed arguments would fill many pages...<br /><br />The best interval might well depend on the ?activity / ?competence of the individual immune defence, which will determine the number of divisions of a single B.b reverted from the "spore" form. If a doubling of number takes 2 days about 1000 B.b would result in about 3 weeks - but possibly the multiplication would be slowed by immune cells "becoming aware" of the growing number and starting to fight back. Then the next pulse hits - and a new "cycle" begins.<br />Anonymousnoreply@blogger.com