Quickly posting this fascinating entry on Spirochetes Unwound that you might want to read:
Does Borrelia burgdorferi cause an inadequate antibody response by altering B cell activation in the lymph node?
One of the characteristic features of Lyme disease is lymphadenopathy or swollen lymph nodes. It's not too surprising when a lymph node draining a site of infection swells. However when investigators looked at the lymph node draining the inoculation site of Borrelia burgdorferi in mice, they found that the spirochete had somehow altered the course of activation of B cells producing the antibodies that targeted the spirochete.
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