Vector Borne Zoonotic Dis. 2012 May 23. [Epub ahead of print]
Critical Analysis of Treatment Trials of Rhesus Macaques Infected with Borrelia burgdorferi Reveals Important Flaws in Experimental Design.
Wormser GP, Baker PJ, O'Connell S, Pachner AR, Schwartz I, Shapiro ED.
A critical analysis of two treatment trials of Chinese rhesus macaques infected with Borrelia burgdorferi indicates that insufficient attention was placed on documenting the blood levels, pharmacokinetics, and pharmacodynamic parameters of the antibiotics used in this host. Consequently, it is impossible to conclude that the findings have validity in judging the efficacy of doxycycline or ceftriaxone for the treatment of Borrelia burgdorferi in this animal model.
PMID: 22620495 [PubMed - as supplied by publisher]
Full text of this critique is available here:
The full text of the original study which is the focus of this critique is here:
Related material on Camp Other blog:
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- Embers et al Rhesus Macaque Study Correction Issued
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- Why Aren't Persisting Spirochetes Enough Evidence Of Infection?
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