Monday, May 30, 2011

0 Paper: Factors Affecting Duration of CFS in Pediatric Patients

Indian J Pediatr. 2011 May 27. [Epub ahead of print]

Factors Affecting Duration of Chronic Fatigue Syndrome in Pediatric Patients.
Petrov D, Marchalik D, Sosin M, Bal A.

UMDNJ/Robert Wood Johnson Medical School, New Brunswick, NJ, USA.


To determine factors affecting duration of chronic fatigue syndrome (CFS) in pediatric patients.

This Retrospective cohort consisted of patients with CFS at the regional referral infectious disease clinic for evaluation of fatigue in children and adolescents. Demographic, clinical, and laboratory data were analyzed to identify the impact on duration and severity of pediatric CFS.

A total number of 53 predominantly white (98.1%) patients with CFS, aged 9-18 years, were included in the study. Other than fatigue, headaches and sleep disturbance were the most common symptoms of pediatric CFS. Seropositive status for Borrelia burgdorferi (B. burgdorferi) and Epstein-Barr virus (EBV) was identified in 66% of the patients with the diagnosis of CFS by CDC criteria. No association was found between the CFS symptoms, gender, or age at diagnosis and duration of fatigue symptoms. Duration of CFS was associated with high Body-Mass Index (BMI) in a regression model after adjustment for patient's age, gender, and seropositive status for B. burgdorferi and/or EBV (0.34 ± 0.15, P < 0.04).

BMI is significantly associated with prolonged duration of CFS.

CO Comments:

I really need to get hold of the full text of this paper.

Interesting how they pointed out that 66% of their patients were seropositive for Borrelia burgdorferi and Epstein-Barr Virus by CDC criteria, but the emphasis in the paper abstract conclusion is only on the correlation between Body-Mass Index and duration of CFS in patients.

What percentage of patients had Lyme disease versus EBV infections? The breakdown isn't clear.

And here comes an additional question: What relationship is there - if any - between BMI and duration of illness?


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