I find what Dr. Barthold had to say about persistence to be very interesting.
(EDIT: Unfortunately, the strict terms about republishing any portion of the transcript were pointed out to me and I had to remove Barthold's quotes from this page - please refer to the transcript above in following what I say below.)
Did anyone else listen to the show or read the transcript and catch what he said about this:
The remaining organisms - potentially these persister cells - are in connective tissue and not eliciting inflammatory change. He sees very little inflammation in the animals he has tested and in which he found persistent spirochetes.
Yet when he removes the bacteria from a mouse and puts it in a new mouse, the spirochetes cause inflammation all over again.
What's up with that? Pretty strange, isn't it?
Can one form a hypothesis about why this is happening or at least take a shot at it?
I have a few ideas about this and will be putting them in comments in this post over the next few days, providing readers with the disclaimer that they are hypothetical and not to be taken as confirmed fact. Someone else will need to do the research on this issue.
Does anyone else here reading along have their own hypothesis about why this is happening - why after antibiotic treatment, he found persistent bacteria in these animals - yet they are not causing inflammation?
This work by Camp Other is licensed under a Creative Commons
Attribution-NonCommercial-ShareAlike 3.0 Unported License.